abstract：OBJECTIVE:To study the feasibility and validity of a two-step telephone screening procedure for symptomatic knee and hip osteoarthritis (OA) in the general population. METHOD:The screening questionnaire was based on signs and symptoms, previous diagnosis of OA and validated OA criteria. A random sample of telephone nu...

journal_title：Annals of the rheumatic diseases

authors： Roux CH,Saraux A,Mazieres B,Pouchot J,Morvan J,Fautrel B,Testa J,Fardellone P,Rat AC,Coste J,Guillemin F,Euller-Ziegler L,KHOALA Osteoarthritis Group.

更新日期：2008-10-01 00:00:00

abstract：OBJECTIVES:To report the results of a pilot study using rituximab combined with Peg-interferon (IFN) alpha2b-ribavirin in severe refractory hepatitis C virus (HCV) related mixed cryoglobulinaemia (MC) vasculitis. METHODS:Sixteen consecutive patients with severe HCV-MC vasculitis that were resistant (n = 11) or relapse...

journal_title：Annals of the rheumatic diseases

authors： Saadoun D,Resche-Rigon M,Sene D,Perard L,Karras A,Cacoub P

更新日期：2008-10-01 00:00:00

abstract：OBJECTIVES:Recent animal studies have revealed critical roles of interleukin (IL)17, which is produced by a newly identified subset of helper T cells, Th17 cells, in the development of autoimmune diseases including arthritis. However, in human rheumatoid arthritis (RA), detailed characteristics and the prevalence of Th...

journal_title：Annals of the rheumatic diseases

authors： Yamada H,Nakashima Y,Okazaki K,Mawatari T,Fukushi JI,Kaibara N,Hori A,Iwamoto Y,Yoshikai Y

更新日期：2008-09-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:The Fc receptor-like 3 (FCRL3) gene -169T>C single nucleotide polymorphism (SNP) has been reported to be associated with several autoimmune diseases (AIDs) in Japanese populations. However, association results in other populations have been conflicting. Therefore, we investigated this SNP in a...

journal_title：Annals of the rheumatic diseases

authors： Eike MC,Nordang GB,Karlsen TH,Boberg KM,Vatn MH,IBSEN study group.,Dahl-Jørgensen K,Rønningen KS,Joner G,Flatø B,Bergquist A,Thorsby E,Førre O,Kvien TK,Undlien DE,Lie BA

更新日期：2008-09-01 00:00:00

abstract：AIM:to evaluate the effects of adalimumab, etanercept and infliximab on disease activity, functional ability and quality of life and the medication costs in a naturalistic design. METHODS:All patients from the Dutch Rheumatoid Arthritis Monitoring (DREAM) register starting on tumour necrosis factor (TNF)alpha-blocking...

journal_title：Annals of the rheumatic diseases

authors： Kievit W,Adang EM,Fransen J,Kuper HH,van de Laar MA,Jansen TL,De Gendt CM,De Rooij DJ,Brus HL,Van Oijen PC,Van Riel PC

更新日期：2008-09-01 00:00:00

abstract：OBJECTIVE:To assess the effects of tumour necrosis factor (TNF) antagonist therapy on B lymphocyte stimulator (BLyS) expression in patients with rheumatoid arthritis (RA). METHODS:Blood from 38 patients with RA from a single centre was collected prior to and following initiation of TNF antagonist therapy. Plasma BLyS ...

journal_title：Annals of the rheumatic diseases

authors： La DT,Collins CE,Yang HT,Migone TS,Stohl W

更新日期：2008-08-01 00:00:00

abstract：OBJECTIVE:To determine whether the heterogeneous clinical response to tumour necrosis factor (TNF)alpha blocking therapy in rheumatoid arthritis (RA) can be predicted by TNFalpha expression in the synovium before initiation of treatment. METHODS:Prior to initiation of infliximab treatment, arthroscopic synovial tissue...

journal_title：Annals of the rheumatic diseases

authors： Wijbrandts CA,Dijkgraaf MG,Kraan MC,Vinkenoog M,Smeets TJ,Dinant H,Vos K,Lems WF,Wolbink GJ,Sijpkens D,Dijkmans BA,Tak PP

更新日期：2008-08-01 00:00:00

abstract：BACKGROUND:We report on a workshop on ethical and legal constraints on data sharing between countries in multinational epidemiologic research in Europe that was held in January 2007 in Potsdam, Germany. The participants were experienced epidemiologic and clinical researchers from eight European countries. The aim of th...

journal_title：Annals of the rheumatic diseases

authors： Zink A,Silman AJ

更新日期：2008-07-01 00:00:00

abstract：OBJECTIVE:To evaluate the presence of anti-PDGFR-alpha antibodies by immunological methods in patients with systemic sclerosis (SSc). METHODS:Fifty-eight women diagnosed with SSc and 36 healthy women controls were included. IgG anti-PDGFR-alpha were measured by ELISA and immunoblot. Associations with clinical and immu...

journal_title：Annals of the rheumatic diseases

authors： Balada E,Simeón-Aznar CP,Ordi-Ros J,Rosa-Leyva M,Selva-O'Callaghan A,Pardos-Gea J,Fonollosa-Pla V,Vilardell-Tarrés M

更新日期：2008-07-01 00:00:00

abstract：OBJECTIVE:To investigate the association of a recently described classification of Human leukocyte antigen (HLA)-DRB1 shared epitope alleles with rheumatoid factors (RF) and anti-cyclic citrullinated peptide (CCP) production and radiological severity in rheumatoid arthritis (RA). METHODS:Patients with RA (n = 962) wer...

journal_title：Annals of the rheumatic diseases

authors： Mewar D,Marinou I,Coote AL,Moore DJ,Akil M,Smillie D,Dickson MC,Binks MH,Montgomery DS,Wilson AG

更新日期：2008-07-01 00:00:00

abstract：BACKGROUND:An association between major histocompatibility complex (MHC) genes, particularly those within the class II HLA region, and rheumatoid arthritis (RA) is well established, and accounts for an estimated 30% of the genetic component in RA. The MHC class II transactivator gene (MHC2TA) on chromosome 16p13 has re...

journal_title：Annals of the rheumatic diseases

authors： Bronson PG,Criswell LA,Barcellos LF

更新日期：2008-07-01 00:00:00

abstract：OBJECTIVES:Few studies have addressed the natural course of, or prognostic factors for the salivary and lacrimal function in primary Sjögren syndrome (SS). Except for the early stages, glandular function has been seemingly stable, and SS A antigen (SSA) seropositivity and hypocomplementemia may predict a decline in the...

journal_title：Annals of the rheumatic diseases

authors： Haldorsen K,Moen K,Jacobsen H,Jonsson R,Brun JG

更新日期：2008-07-01 00:00:00

abstract：OBJECTIVES:An abnormal CD4+ T cell subset related to inflammation exposure (inflammation-related cells, IRC) has been identified in rheumatoid arthritis (RA). Patients with inflammatory and non-inflammatory diseases were used to examine the relationship between inflammation and this T cell subset in vivo. METHODS:Bloo...

journal_title：Annals of the rheumatic diseases

authors： Burgoyne CH,Field SL,Brown AK,Hensor EM,English A,Bingham SL,Verburg R,Fearon U,Lawson CA,Hamlin PJ,Straszynski L,Veale D,Conaghan P,Hull MA,van Laar JM,Tennant A,Emery P,Isaacs JD,Ponchel F

更新日期：2008-06-01 00:00:00

abstract：OBJECTIVE:The RCA alpha block (Regulators of Complement Activation, 1q32) contains critical complement regulatory genes such as CR1 and MCP. This study examined RCA alpha block haplotype associations with both disease susceptibility and diversification of the anti-Ro/La autoantibody response in primary Sjögren syndrome...

journal_title：Annals of the rheumatic diseases

authors： Lester S,McLure C,Williamson J,Bardy P,Rischmueller M,Dawkins RL

更新日期：2008-06-01 00:00:00

abstract：OBJECTIVE:To identify potential risk factors for the onset of inflammatory arthritis (IA) in a large cohort of patients with psoriatic arthritis (PsA) of recent onset. METHODS:We recruited cases with psoriasis and an onset of IA within the past 5 years. Controls were patients who had psoriasis but no arthritis. We ass...

journal_title：Annals of the rheumatic diseases

authors： Pattison E,Harrison BJ,Griffiths CE,Silman AJ,Bruce IN

更新日期：2008-05-01 00:00:00

abstract：:We showed previously that the attachment of synovial fibroblasts to laminin (LM)-111 in the presence of transforming growth factor-beta induces significant expression of the matrix metalloproteinase (MMP)-3. Here we go on to investigate the regulation of additional MMPs and their specific tissue inhibitors of matrix p...

journal_title：Annals of the rheumatic diseases

authors： Warstat K,Pap T,Klein G,Gay S,Aicher WK

更新日期：2008-04-01 00:00:00

abstract：OBJECTIVE:B lymphocytes have been implicated in the pathogenesis of lupus and other autoimmune diseases, resulting in the introduction of B cell-directed therapies. Epratuzumab, a humanised anti-CD22 monoclonal antibody, is currently in clinical trials, although its effects on patients' B cells are not completely under...

journal_title：Annals of the rheumatic diseases

authors： Jacobi AM,Goldenberg DM,Hiepe F,Radbruch A,Burmester GR,Dörner T

更新日期：2008-04-01 00:00:00

abstract：OBJECTIVE:To describe granuloma annulare (GA) skin lesion development in patients during anti-tumour necrosis factor (TNF) therapy. METHODS:199 patients with rheumatoid arthritis and 127 suffering from spondyloarthropathies treated with anti-TNF antagonists were analysed to identify skin lesions suggesting GA. RESULT...

journal_title：Annals of the rheumatic diseases

authors： Voulgari PV,Markatseli TE,Exarchou SA,Zioga A,Drosos AA

更新日期：2008-04-01 00:00:00

abstract：BACKGROUND:Antibodies targeting citrullinated antigens are specific for rheumatoid arthritis (RA). Citrullination is catalysed by the peptidylarginine deiminase (PAD) enzyme family. Critical enzymes are often targeted by disease-specific antibodies in complex immune-mediated diseases. Here, we have tested for autoantib...

journal_title：Annals of the rheumatic diseases

authors： Halvorsen EH,Pollmann S,Gilboe IM,van der Heijde D,Landewé R,Ødegård S,Kvien TK,Molberg Ø

更新日期：2008-03-01 00:00:00

abstract：BACKGROUND:Physical function in rheumatoid arthritis (RA) has reversible and irreversible components, and is typically assessed by the Health Assessment Questionnaire Disability Index (HAQ). Since irreversible components are expected to increase with longer duration of RA and reduce the ability for improvement in physi...

journal_title：Annals of the rheumatic diseases

authors： Aletaha D,Strand V,Smolen JS,Ward MM

更新日期：2008-02-01 00:00:00

abstract：AIMS:The aim of this work was to assess the feasibility of using dynamic contrast enhanced (DCE) MRI of bone marrow oedema, to compare it with conventional marrow oedema scoring systems, and to determine the effects of anti-tumour necrosis factor (TNF)alpha therapy. METHODS:The wrist and metacarpophalangeal (MCP) join...

journal_title：Annals of the rheumatic diseases

authors： Hodgson R,Grainger A,O'Connor P,Barnes T,Connolly S,Moots R

更新日期：2008-02-01 00:00:00

abstract：BACKGROUND:The PTPN22 gene has been widely confirmed as a susceptibility gene for rheumatoid arthritis (RA) in populations of Northern European descent. The aim of the current study was to explore the role of variants spanning the PTPN22 gene in determining susceptibility to and outcome of inflammatory polyarthritis (I...

journal_title：Annals of the rheumatic diseases

authors： Naseem H,Thomson W,Silman A,Worthington J,Symmons D,Barton A

更新日期：2008-02-01 00:00:00

abstract：OBJECTIVE:To analyse fibronectin (FN) gene polymorphisms in type II mixed cryoglobulinemic syndrome (MCsn), an immune-complex mediated systemic vasculitis linked to hepatitis C virus (HCV) infection and characterised by rheumatoid factor (RF) positive B-cell proliferation at high risk for the progression into non-Hodgk...

journal_title：Annals of the rheumatic diseases

authors： Fabris M,Quartuccio L,Salvin S,Pozzato G,De Re V,Mazzaro C,Ferri C,Baldini C,De Vita S

更新日期：2008-01-01 00:00:00

abstract：OBJECTIVE:To study prescription patterns of biological treatment in rheumatoid arthritis (RA) patients in southern Sweden, a region with no formal or economic restrictions for the use of biological treatment in rheumatological diseases. Specifically, we studied conformity with the national Swedish guidelines for biolog...

journal_title：Annals of the rheumatic diseases

authors： Söderlin MK,Geborek P

更新日期：2008-01-01 00:00:00

abstract：OBJECTIVES:To describe presentation and outcome of patients with scleroderma renal crisis (SRC). METHODS:SRC was defined as rapidly progressive oliguric renal insufficiency and/or rapidly progressive arterial hypertension occurring during the course of systemic sclerosis (SSc). Chronic dialysis-free survival was analy...

journal_title：Annals of the rheumatic diseases

authors： Teixeira L,Mouthon L,Mahr A,Berezné A,Agard C,Mehrenberger M,Noël LH,Trolliet P,Frances C,Cabane J,Guillevin L,Group Français de Recherche sur le Sclérodermie (GFRS).

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Vascular damage is a key pathological process in systemic sclerosis (SSc) and accounts for significant disease-related morbidity. To determine the clinical burden of severe digital vasculopathy (SDV), we have reviewed hospital-based treatment for this important complication of SSc in a large single centre co...

journal_title：Annals of the rheumatic diseases

authors： Nihtyanova SI,Brough GM,Black CM,Denton CP

更新日期：2008-01-01 00:00:00

abstract：OBJECTIVE:To assess associations between joint-specific hand symptoms and self-reported and performance-based functional status. METHODS:Participants were from the population-based Johnston County Osteoarthritis Project. Symptoms in the distal interphalangeal (DIP), proximal interphalangeal (PIP), first carpometacarpa...

journal_title：Annals of the rheumatic diseases

authors： Elliott AL,Kraus VB,Fang F,Renner JB,Schwartz TA,Salazar A,Huguenin T,Hochberg MC,Helmick CG,Jordan JM

更新日期：2007-12-01 00:00:00

abstract：OBJECTIVE:To conduct a cross-sectional review of non-selected consecutive outpatients with rheumatoid arthritis (RA) as part of standard clinical care in 15 countries for an overview of the characteristics of patients with RA. METHODS:The review included current disease activity using data from clinical assessment and...

journal_title：Annals of the rheumatic diseases

authors： Sokka T,Kautiainen H,Toloza S,Mäkinen H,Verstappen SM,Lund Hetland M,Naranjo A,Baecklund E,Herborn G,Rau R,Cazzato M,Gossec L,Skakic V,Gogus F,Sierakowski S,Bresnihan B,Taylor P,McClinton C,Pincus T,QUEST-RA Group.

更新日期：2007-11-01 00:00:00

abstract：:The CAMERA study shows that using methotrexate in a tight control setting might lead to considerable improvement in disease activity in early rheumatoid arthritis See linked article p 1443. ...

journal_title：Annals of the rheumatic diseases

authors： Bijlsma JW,Weinblatt ME

更新日期：2007-11-01 00:00:00

abstract：:Sepsis is a severe complication of abdominal infections such as peritonitis and is associated with high mortality. Unfortunately, the molecular mechanisms controlling the development of sepsis are still incompletely understood. Interestingly, the interleukin (IL) 12 family member IL27 seems to play a key role in sepsi...

journal_title：Annals of the rheumatic diseases

authors： Neurath MF

更新日期：2007-11-01 00:00:00

abstract：:T cells from patients with systemic lupus erythematosus exhibit a notable array of defects that probably contribute to the origin and development of the disease. Such abnormalities include an abnormal response to stimulation, aberrant expression of molecules that play key roles in intracellular signalling pathways, al...

journal_title：Annals of the rheumatic diseases

authors： Crispín JC,Kyttaris V,Juang YT,Tsokos GC

更新日期：2007-11-01 00:00:00

abstract：:Recent data are presented which indicate a critical role for interleukin (IL)-18 in rheumatoid arthritis (RA). The T cells and macrophages invading the synovium or in the synovial fluid are the chief cellular targets of IL-18 in RA. Neutrophils, dendritic cells and endothelial cells may also be cellular mediators of I...

journal_title：Annals of the rheumatic diseases

authors： Dai SM,Shan ZZ,Xu H,Nishioka K

更新日期：2007-11-01 00:00:00

abstract：BACKGROUND:A great deal of evidence has shown that non-human leucocyte antigen (HLA)-B27 genes may play crucial roles in the aetiology of ankylosing spondylitis (AS), but there is little evidence of a relationship with tumour necrosis factor (TNF)alpha gene variation. One functional single-nucleotide polymorphism (SNP)...

journal_title：Annals of the rheumatic diseases

authors： Zhu X,Wang Y,Sun L,Song Y,Sun F,Tang L,Huo Z,Li J,Yang Z

更新日期：2007-11-01 00:00:00

abstract：BACKGROUND:Certain sequences present in the hypervariable region of human leucocyte antigen (HLA)-DRB1 known as the shared epitope (SE) are hypothesised to increase the risk of rheumatoid arthritis (RA), whereas alleles encoding aspartic acid at position 70 (D70 alleles) may have a protective effect. METHODS:Patient H...

journal_title：Annals of the rheumatic diseases

authors： Shadick NA,Heller JE,Weinblatt ME,Maher NE,Cui J,Ginsburg G,Coblyn J,Anderson R,Solomon DH,Roubenoff R,Parker A

更新日期：2007-11-01 00:00:00

abstract：OBJECTIVES:Increased numbers of neutrophils expressing proteinase 3 on their membrane (mPR3) have been reported in anti-neutrophil cytoplasm antibody (ANCA)-associated vasculitis (AAV) and are suggested to be involved in AAV immunopathogenesis. In most studies, neutrophils were analysed for mPR3 expression without prim...

journal_title：Annals of the rheumatic diseases

authors： van Rossum AP,Huitema MG,Stegeman CA,Bijl M,de Leeuw K,Van Leeuwen MA,Limburg PC,Kallenberg CG

更新日期：2007-10-01 00:00:00

abstract：OBJECTIVE:A study was undertaken to investigate the in vivo pathogenic role of Toll-like receptor 4 (TLR-4) in the antiphospholipid syndrome (APS) by studying the thrombogenic antiphospholipid (aPL) activity in lipopolysaccharide (LPS) non-responsive (LPS-/-) mice and the association between tlr4 gene polymorphisms and...

journal_title：Annals of the rheumatic diseases

authors： Pierangeli SS,Vega-Ostertag ME,Raschi E,Liu X,Romay-Penabad Z,De Micheli V,Galli M,Moia M,Tincani A,Borghi MO,Nguyen-Oghalai T,Meroni PL

更新日期：2007-10-01 00:00:00

abstract：OBJECTIVES:Antiphospholipid antibodies (aPLA) have been shown to enhance thrombus formation by increasing the expression of adhesive receptors such as P-selectin on endothelial cells. The P-selectin counter-receptor on leucocytes is P-selectin glycoprotein ligand-1 (PSGL-1). We have previously described a variable numb...

journal_title：Annals of the rheumatic diseases

authors： Diz-Kucukkaya R,Inanc M,Afshar-Kharghan V,Zhang QE,López JA,Pekcelen Y

更新日期：2007-10-01 00:00:00

abstract：OBJECTIVE:To investigate the relationship of the polymorphic enhancer HS1,2 central to the 3' enhancer complex regulatory region (IgH3'EC) of the immunoglobulin heavy chain genes with systemic sclerosis (SSc) disease and compare it with HLA-DR and DQ associations. METHODS:A total of 116 patients with SSc were classifi...

journal_title：Annals of the rheumatic diseases

authors： Frezza D,Giambra V,Tolusso B,De Santis M,Bosello S,Vettori S,Triolo G,Valentini G,Ferraccioli G

更新日期：2007-09-01 00:00:00

abstract：BACKGROUND:Osteoarthritis of the hands is a prevalent musculoskeletal disease with a considerable effect on patients' lives, but knowledge and research results in the field of hand osteoarthritis are limited. Therefore, the Disease Characteristics in Hand OA (DICHOA) initiative was founded in early 2005 with the aim of...

journal_title：Annals of the rheumatic diseases

authors： Kloppenburg M,Stamm T,Watt I,Kainberger F,Cawston TE,Birrell FN,Petersson IF,Saxne T,Kvien TK,Slatkowsky-Christensen B,Dougados M,Gossec L,Breedveld FC,Smolen JS

更新日期：2007-09-01 00:00:00

abstract：BACKGROUND:Matrix metalloproteinase (MMP)1, interleukin(IL)6 and vitamin D receptor (VDR) have been implicated in the biological cascade of events initiated by particulate wear debris and bacterial infection, resulting in periprosthetic bone loss around loosened total hip replacements (THRs). The individual responses t...

journal_title：Annals of the rheumatic diseases

authors： Malik MH,Jury F,Bayat A,Ollier WE,Kay PR

更新日期：2007-08-01 00:00:00